KANSAS CITY, MO—Three successful young Stowers scientists have been named the recipients of highly competitive awards, including a research fellowship from American Cancer Society research fellowship, a prize by the Portuguese Foundation for Science and Technology for an outstanding doctoral thesis in molecular medicine and a DeLill Nasser Award for Professional Development.

Tamara Potapova, Ph.D., submitted a winning fellowship proposal to the American Cancer Society to study aneuploidy or abnormal chromosome number, a prominent hallmark of cancer cells. The prestigious $150,000 fellowship is intended to encourage the nation's most-promising young investigators to pursue innovative research projects that have the potential to transform the way we prevent, diagnose and treat cancer.

Potapova, a postdoctoral researcher in the lab of Stowers Investigator Rong Li, Ph.D., will be using the funds to uncover the molecular mechanisms that allow cells with extra sets of chromosomes to slip through a “ploidy”-checkpoint and produce aneuploid progeny. She hopes that her work may lead to a better understanding of carcinogenesis and potentially translate into new targets for anti-cancer drug development

Inês Mendes Pinto’s doctoral thesis was recognized for its outstanding level of scholarship by the Portuguese Foundation for Science and Technology.  In a wide-reaching interdisciplinary approach, Mendes Pinto, Ph.D., combined traditional imaging and genetic tools with physics and mathematics to study the biomechanics of the molecular machinery that physically separates cell during cell division and the signals that initiate the process.

The work, which Mendes Pinto performed under the mentorship of Stowers Investigator Rong Li, broke new ground in the field of cytokinesis, the final stage of the process that separates dividing cells.  It also provided new insight into the mechanisms that generate contractile forces in non-muscle cells, which play an important role in cell division but also many other processes such as cell shape changes, cell adhesion and motility.

Guangbo Chen, a graduate student in Li’s lab, has been selected by the Genetics Society of America as one of only six students to receive a DeLill Nasser Award for Professional Development in Genetics. The award is named in honor of DeLill Nasser (1929-2000), who was instrumental in promoting genetics research during her tenure as National Science Foundation Program Director in Eukaryotic Genetics. She was particularly supportive of young scientists, those at the beginning of their careers, and those trying to open new areas of genetic inquiry.

As part of his graduate thesis, Chen was able to show that under stressful conditions yeast cells’ genomes become unstable, readily acquiring or losing whole chromosomes to enable rapid adaption to changing environments. He will apply the funds toward attending the course “Gene Regulatory Networks for Development” held at the Marine Biological Lab at Woods Hole.

About the Stowers Institute

The Stowers Institute for Medical Research is a non-profit, basic biomedical research organization dedicated to improving human health by studying the fundamental processes of life. Jim Stowers, founder of American Century Investments, and his wife Virginia opened the Institute in 2000. Since then, the Institute has spent over $900 million dollars in pursuit of its mission.

Currently the Institute is home to over 550 researchers and support personnel; 22 independent research programs; and more than a dozen technology development and core facilities.