News
23 May 2023
A niche for cancer
Stowers scientists are unraveling the mechanisms governing cancer stem cells
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Linheng Li
B.S., Biology, Fudan University
M.S., Molecular and Cellular Biology, New York University Medical School
Ph.D., Molecular and Cellular Biology, New York University Medical School
Stowers provides one of the best support systems for a scientist, not just financially, but also technologically and culturally
Linheng's Profile
Research Areas
Development and Regeneration, Genetics and Genomics, Molecular and Cell Biology
Courses Taught
Laboratory Rotation; Thesis Laboratory
Honors
2018
The University of Kansas Cancer Center Director’s William Jewell Team Science Award
2017
The University of Kansas Cancer Center Director’s Outstanding Basic Science Award
2013
Fellow, American Gastroenterological Association
2011
Fellow, American Association for the Advancement of Science
2005
Basil O’Connor Scholar
2004
Hudson Prize
2003
Award for Excellence in Life Science, Missouri Biotechnology Association
Linheng Li, Ph.D., joined the Stowers Institute in 2000, and is an Investigator and faculty member of the graduate school.
Among the first scientists appointed to the Stowers faculty, Li is an internationally recognized leader on the biology of adult stem cells and the specialized niches that harbor stem cells in many organs and tissues of humans and other mammals.
Li earned a B.S. in biology and genetics from Fudan University in Shanghai and an M.S. and Ph.D. in molecular and cellular biology from New York University. He completed his postdoctoral training under Leroy Hood, Ph.D., the “father” of automatic DNA sequencing, at the University of Washington. In collaboration with Irv Weissman, Ph.D., at Stanford University, Li explored the mysterious stem cells by investigating specific genes expressed in stem cells via large scale sequencing.
Li is an active member of the Kansas City community. He serves as liaison between the Stowers Institute and The University of Kansas Cancer Center and co-leads the center’s cancer biology program.
Related News
News
20 April 2020
What’s old is new again
The study’s researchers found that low doses of the anthracycline antibiotic doxorubicin inhibit the interaction between two molecular pathways that work closely together to promote tumor growth and resistance to therapy. The targeted approach also clears the way for cancer-targeting immune cells to do their work, an unexpected and novel finding, according to the study authors.
Read Article
Press Release
15 January 2019
Scientists have identified a bone marrow backup system
New research from the Stowers Institute for Medical Research has identified a backup for an important biological system – the hematopoietic system, whose adult stem cells constantly replenish the body’s blood supply.
Read Article
Featured Publications
He X, Smith SE, Chen S, Li H, Wu D, Meneses-Giles PI, Wang Y, Hembree M, Yi K, Zhao X, Guo F, Unruh JR, Maddera LE, Yu Z, Scott A, Perera A, Wang Y, Zhao C, Bae K, Box A, Haug JS, Tao F, Hu D, Hansen DM, Qian P, Saha S, Dixon D, Anant S, Zhang D, Lin EH, Sun W, Wiedemann LM, Li L. Cell Rep. 2021;36:109674.doi: 10.1016/j.celrep.2021.109674.
Overcoming Wnt-beta-catenin dependent anticancer therapy resistance in leukaemia stem cells
Perry JM, Tao F, Roy A, Lin T, He XC, Chen S, Lu X, Nemechek J, Ruan L, Yu X, Dukes D, Moran A, Pace J, Schroeder K, Zhao M, Venkatraman A, Qian P, Li Z, Hembree M, Paulson A, He Z, Xu D, Tran TH, Deshmukh P, Nguyen CT, Kasi RM, Ryan R, Broward M, Ding S, Guest E, August K, Gamis AS, Godwin A, Sittampalam GS, Weir SJ, Li L. Nat Cell Biol. 2020;22:689-700
Zhao M, Tao F, Venkatraman A, Li Z, Smith SE, Unruh J, Chen S, Ward C, Qian P, Perry JM, Marshall H, Wang J, He XC, Li L. Cell Rep. 2019;26:652-669 e656.
Qian P, De Kumar B, He XC, Nolte C, Gogol M, Ahn Y, Chen S, Li Z, Xu H, Perry JM, Hu D, Tao F, Zhao M, Han Y, Hall K, Peak A, Paulson A, Zhao C, Venkatraman A, Box A, Perera A, Haug JS, Parmely T, Li H, Krumlauf R, Li L. Cell Stem Cell. 2018;22:740-754 e747.
Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion
Li Z, Qian P, Shao W, Shi H, He XC, Gogol M, Yu Z, Wang Y, Qi M, Zhu Y, Perry JM, Zhang K, Tao F, Zhou K, Hu D, Han Y, Zhao C, Alexander R, Xu H, Chen S, Peak A, Hall K, Peterson M, Perera A, Haug JS, Parmely T, Li H, Shen B, Zeitlinger J, He C, Li L. Cell Res. 2018. Author Correction: Cell Res 2018:1-14. doi.org/10.1038/s41422-018-0072-0. Published online July 2018.;28:904-917.
Qian P, He XC, Paulson A, Li Z, Tao F, Perry JM, Guo F, Zhao M, Zhi L, Venkatraman A, Haug JS, Parmely T, Li H, Dobrowsky RT, Ding WX, Kono T, Ferguson-Smith AC, Li L. Cell Stem Cell. 2016;18:214-228.
