The Transgenic and Reproductive Technologies group provides specialized services for Stowers scientists that utilize genetically modified organisms.
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Publications
The Transgenic and Reproductive Technologies group is composed of team members who possess extensive knowledge and expertise to create genetically modified organisms using advanced technology. This group works in partnership with researchers from investigator labs and other Technology Centers to develop and protect the variants that are used in ongoing scientific studies.
The team offers a variety of technical services including applying CRISPR/Cas9 and standard transgenic techniques to well-studied and new research organisms, rederivation of existing health-compromised models, the recovery and rescue of strains through in vitro fertilization and the cryopreservation and storage of germplasm from the research organisms.
Technologies
Cloning, surgery, preservation, in vitro fertilization are just some of the capabilities of the Transgenic and Reproductive Technologies team.
Press Release
01 January 2021
What if degenerative eye conditions could be detected and treated before vision is impaired? Recent findings from the Xie Lab point to the ciliary body as a key to unlocking this possibility.
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Press Release
07 August 2020
Scientists in the Bazzini Lab and collaborators have harnessed CRISPR technology to target gene messages in animal model embryos to gain a better understanding of the early stages of vertebrate development.
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News
16 June 2020
Scientists at the Stowers Institute have shown that a dysfunctional placenta can play a previously unrecognized role during the earliest stages of development in mouse models
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News
20 April 2020
The study’s researchers found that low doses of the anthracycline antibiotic doxorubicin inhibit the interaction between two molecular pathways that work closely together to promote tumor growth and resistance to therapy. The targeted approach also clears the way for cancer-targeting immune cells to do their work, an unexpected and novel finding, according to the study authors.
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Pang J, Le L, Zhou Y, Tu R, Hou Q, Tsuchiya D, Thomas N, Wang Y, Yu Z, Alexander R, Thexton M, Lewis B, Corbin T, Durnin M, Li H, Ashery-Padan R, Yan D, Xie T. Cell Rep. 2021;34:108603. doi: 108610.101016/j.celrep.102020.108603.
CRISPR-Cas13d Induces Efficient mRNA Knockdown in Animal Embryos
Kushawah G, Hernandez-Huertas L, Abugattas-Nunez Del Prado J, Martinez-Morales JR, DeVore ML, Hassan H, Moreno-Sanchez I, Tomas-Gallardo L, Diaz-Moscoso A, Monges DE, Guelfo JR, Theune WC, Brannan EO, Wang W, Corbin TJ, Moran AM, Sanchez Alvarado A, Malaga-Trillo E, Takacs CM, Bazzini AA, Moreno-Mateos MA. Dev Cell. 2020;54:805-817 e807.
Aoto K, Sandell LL, Butler Tjaden NE, Yuen KC, Watt KE, Black BL, Durnin M, Trainor PA. Dev Biol. 2015;402:3-16.
The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration.
Suraneni P, Rubinstein B, Unruh JR, Durnin M, Hanein D, Li R. J Cell Biol. 2012;197:239-251.
Distinct Signals Conveyed to Pheromone Concentrations to the Mouse Vomeronasal Organ.
He J, Ma L, Kim S, Schwartz J, Santilli M, Wood C, Durnin MH, Yu CR. J Neurosci. 2010;30:7473-7483.
Iulianella A, Sharma M, Vanden Heuvel GB, Trainor PA. Development. 2009;136:2329-2334.
